Triple-Negative Breast Cancer: Current Understanding and Future Therapeutic Breakthrough Targeting Cancer Stemness
Identifieur interne : 000307 ( Main/Exploration ); précédent : 000306; suivant : 000308Triple-Negative Breast Cancer: Current Understanding and Future Therapeutic Breakthrough Targeting Cancer Stemness
Auteurs : Kha-Liang Lee [Taïwan] ; Yung-Che Kuo [Taïwan] ; Yuan-Soon Ho [Taïwan] ; Yen-Hua Huang [Taïwan]Source :
- Cancers [ 2072-6694 ] ; 2019.
Abstract
Triple-negative breast cancer (TNBC) is cancer that tested as negative for estrogen receptors (ER), progesterone receptors (PR), and excess human epidermal growth factor receptor 2 (HER2) protein which accounts for 15%–20% of all breast cancer cases. TNBC is considered to be a poorer prognosis than other types of breast cancer, mainly because it involves more aggressive phenotypes that are similar to stem cell–like cancer cells (cancer stem cell, CSC). Thus, targeted treatment of TNBC remains a major challenge in clinical practice. This review article surveys the latest evidence concerning the role of genomic alteration in current TNBC treatment responses, current clinical trials and potential targeting sites, CSC and drug resistance, and potential strategies targeting CSCs in TNBC. Furthermore, the role of insulin-like growth factor 1 receptor (IGF-1R) and nicotinic acetylcholine receptors (nAChR) in stemness expression, chemoresistance, and metastasis in TNBC and their relevance to potential treatments are also discussed and highlighted.
Url:
DOI: 10.3390/cancers11091334
PubMed: 31505803
PubMed Central: 6769912
Affiliations:
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TNBC is considered to be a poorer prognosis than other types of breast cancer, mainly because it involves more aggressive phenotypes that are similar to stem cell–like cancer cells (cancer stem cell, CSC). Thus, targeted treatment of TNBC remains a major challenge in clinical practice. This review article surveys the latest evidence concerning the role of genomic alteration in current TNBC treatment responses, current clinical trials and potential targeting sites, CSC and drug resistance, and potential strategies targeting CSCs in TNBC. Furthermore, the role of insulin-like growth factor 1 receptor (IGF-1R) and nicotinic acetylcholine receptors (nAChR) in stemness expression, chemoresistance, and metastasis in TNBC and their relevance to potential treatments are also discussed and highlighted.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bray, F" uniqKey="Bray F">F. 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Gautam</name></author><author><name sortKey="Jaiswal, A" uniqKey="Jaiswal A">A. Jaiswal</name></author><author><name sortKey="Aittokallio, T" uniqKey="Aittokallio T">T. Aittokallio</name></author><author><name sortKey="Al Ali, H" uniqKey="Al Ali H">H. Al-Ali</name></author><author><name sortKey="Wennerberg, K" uniqKey="Wennerberg K">K. Wennerberg</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Lee, Kha Liang" sort="Lee, Kha Liang" uniqKey="Lee K" first="Kha-Liang" last="Lee">Kha-Liang Lee</name></noRegion><name sortKey="Ho, Yuan Soon" sort="Ho, Yuan Soon" uniqKey="Ho Y" first="Yuan-Soon" last="Ho">Yuan-Soon Ho</name><name sortKey="Ho, Yuan Soon" sort="Ho, Yuan Soon" uniqKey="Ho Y" first="Yuan-Soon" last="Ho">Yuan-Soon Ho</name><name sortKey="Ho, Yuan Soon" sort="Ho, Yuan Soon" uniqKey="Ho Y" first="Yuan-Soon" last="Ho">Yuan-Soon Ho</name><name sortKey="Huang, Yen Hua" sort="Huang, Yen Hua" uniqKey="Huang Y" first="Yen-Hua" last="Huang">Yen-Hua Huang</name><name sortKey="Huang, Yen Hua" sort="Huang, Yen Hua" uniqKey="Huang Y" first="Yen-Hua" last="Huang">Yen-Hua Huang</name><name sortKey="Huang, Yen Hua" sort="Huang, Yen Hua" uniqKey="Huang Y" first="Yen-Hua" last="Huang">Yen-Hua Huang</name><name sortKey="Huang, Yen Hua" sort="Huang, Yen Hua" uniqKey="Huang Y" first="Yen-Hua" last="Huang">Yen-Hua Huang</name><name sortKey="Huang, Yen Hua" sort="Huang, Yen Hua" uniqKey="Huang Y" first="Yen-Hua" last="Huang">Yen-Hua Huang</name><name sortKey="Huang, Yen Hua" sort="Huang, Yen Hua" uniqKey="Huang Y" first="Yen-Hua" last="Huang">Yen-Hua Huang</name><name sortKey="Huang, Yen Hua" sort="Huang, Yen Hua" uniqKey="Huang Y" first="Yen-Hua" last="Huang">Yen-Hua Huang</name><name sortKey="Kuo, Yung Che" sort="Kuo, Yung Che" uniqKey="Kuo Y" first="Yung-Che" last="Kuo">Yung-Che Kuo</name><name sortKey="Kuo, Yung Che" sort="Kuo, Yung Che" uniqKey="Kuo Y" first="Yung-Che" last="Kuo">Yung-Che Kuo</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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